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PNA
PNA Gamma PNA
Gamma (γ)-PNA is a backbone-modified PNA that possesses a stereogenic center through modifications introduced at gamma (γ)-carbon of the backbone. Due to the stereogenic center, the gamma-PNA oligo itself forms an alpha-helical structure, thereby reducing the self-aggregation, improving the solubility and forming a more stable duplex with the target DNA. These features provide higher binding affinity to the target. In addition, various modifications such as internal multi-labeling are possible at any gamma (γ)-position. With these advantages, gamma (γ)-PNA can be an attractive material for diagnostics and drug development.
DETAILS
DETAILS
- Various modifications available
- Flexibility for internal labeling and multi-labeling
- Improved solubility and cell permeability
- Decrease of self-aggregation through pre-organized alpha-helical structure
- Superior binding affinity compared with to conventional PNA
Available modifications
- Various modifications by adding another moiety at Lys-gamma modified residue
- Sidechain of Lysine, Glutamic acid, and/or Alanine (as called Lys-gamma, Glu-gamma and Ala-gamma, respectively)
| Criteria | Gamma(γ)-PNA | Conventional PNA |
|---|---|---|
| Backbone modification | Possible | Impossible |
| Labeling flexibility on backbone | O | X |
| Water solubility | Better than conventional PNA | - |
| Binding affinity to DNA | 3~5℃ Higher Tm per modified base | - |
| ΔTm for single mismatch | At least 18℃ | 15℃ |
| Chemical stability | More Stable than conventional PNA | Stable |
| Thermal stability | Good | Good |
