Welcome > Support > Reference Treatises  
Writer Panagene     (Date : 2016-07-13 10:03:48)
Subject [Scientific publications] [2015]IDH Mutation Analysis in Ewing Sarcoma Family Tumors.

J Pathol Transl Med. 2015 May;49(3):257-61. doi: 10.4132/jptm.2015.04.14. Epub 2015 May 15.

IDH Mutation Analysis in Ewing Sarcoma Family Tumors.

Na KY1Noh BJ2Sung JY3Kim YW3Santini Araujo E4Park YK3.

Author information



Isocitrate dehydrogenase (IDH) catalyzes the oxidative decarboxylation of isocitrate to yield α-ketoglutarate (α-KG) with production of reduced nicotinamide adenine dinucleotide (NADH). Dysfunctional IDH leads to reduced production of α-KG and NADH and increased production of 2-hydroxyglutarate, an oncometabolite. This results in increased oxidative damage and stabilization of hypoxia-inducible factor α, causing cells to be prone to tumorigenesis.


This study investigated IDH mutations in 61 Ewing sarcoma family tumors (ESFTs), using a pentose nucleic acid clamping method and direct sequencing.


We identified four cases of ESFTs harboring IDH mutations. The number of IDH1 and IDH2 mutations was equal and the subtype of IDH mutations was variable. Clinicopathologic analysis according to IDH mutation status did not reveal significant results.


This study is the first to report IDH mutations in ESFTs. The results indicate that ESFTs can harbor IDH mutations in previously known hot-spot regions, although their incidence is rare. Further validation with a larger case-based study would establish more reliable and significant data on prevalence rate and the biological significance of IDH mutations in ESFTs.


Isocitrate dehydrogenase; PNA clamping; Sarcoma, Ewing


 No   Subject Writer File Count
   47           [Scientific publications] [2016]Comparison of EGFR .. Panagene 5541
          [Scientific publications] [2015]IDH Mutation Analys.. Panagene 25271
   45           [Scientific publications] [2015]Low frequency of KR.. Panagene 3601
   44           [Scientific publications] [2015]Simultaneous genoty.. Panagene 338
   43           [Scientific publications] [2014]Simultaneous diagno.. Panagene 319
   42           [Scientific publications] [2014]KRAS Mutation Detec.. Panagene 333
   41           [Scientific publications] [2013]Detection of EGFR m.. Panagene 383
   40           [Scientific publications] [2013]Detection and compa.. Panagene 339
   39           [Scientific publications] [2013]Detection of BRAF V.. Panagene 352
   38           [Scientific publications] [2013]Comparison of Direc.. Panagene 329
   37           [Scientific publications] [PNAClamp]Detection of EG.. Panagene 5679
   36           [Scientific publications] [Clamp]Rapid and Sensitiv.. panagene 6679
   35           [Scientific publications] [PNA microarray] Developm.. Panagene 6991
   34           [Scientific publications] [PANArray] JHDM3A module.. Panagene 1230
   33           [Scientific publications] [PNA Chip vs DNA Chip cli.. Panagene 1411
   32           [Scientific publications] [Panagene publication] PN.. Panagene 1271
   31           [Scientific publications] [Panagene publication] PN.. panagene 1285
   30           [Scientific publications] [Panagene publication] Pe.. panagene 1248
   29           [Scientific publications] [Panagene publication] Hi.. panagene 1228
   28           [Scientific publications] [PNA]Membrane-based hybri.. Panagene 1186

< 1 2 3 >